diff --git a/include/mbedtls/config_psa.h b/include/mbedtls/config_psa.h
index ea822803b9..c46ed56a50 100644
--- a/include/mbedtls/config_psa.h
+++ b/include/mbedtls/config_psa.h
@@ -642,7 +642,8 @@ extern "C" {
 #define PSA_WANT_ECC_MONTGOMERY_255
 #endif
 
-#if defined(MBEDTLS_ECP_DP_CURVE448_ENABLED)
+/* Curve448 is not yet supported via the PSA API (https://github.com/ARMmbed/mbedtls/issues/4249) */
+#if 0 && defined(MBEDTLS_ECP_DP_CURVE448_ENABLED)
 #define MBEDTLS_PSA_BUILTIN_ECC_MONTGOMERY_448 1
 #define PSA_WANT_ECC_MONTGOMERY_448
 #endif
diff --git a/include/psa/crypto_config.h b/include/psa/crypto_config.h
index 97395d8949..bad1e34f2f 100644
--- a/include/psa/crypto_config.h
+++ b/include/psa/crypto_config.h
@@ -84,7 +84,8 @@
 #define PSA_WANT_ECC_BRAINPOOL_P_R1_384         1
 #define PSA_WANT_ECC_BRAINPOOL_P_R1_512         1
 #define PSA_WANT_ECC_MONTGOMERY_255             1
-#define PSA_WANT_ECC_MONTGOMERY_448             1
+/* Curve448 is not yet supported via the PSA API (https://github.com/ARMmbed/mbedtls/issues/4249) */
+//#define PSA_WANT_ECC_MONTGOMERY_448             1
 #define PSA_WANT_ECC_SECP_K1_192                1
 #define PSA_WANT_ECC_SECP_K1_224                1
 #define PSA_WANT_ECC_SECP_K1_256                1